Cancers, Vol. 12, Pages 1284: Acidosis-Induced TGF- β2 Production Promotes Lipid Droplet Formation in Dendritic Cells and Alters Their Potential to Support Anti-Mesothelioma T Cell Response

In conclusion, our study has identified that acidic mesothelioma milieu drives DC dysfunction and altered T cell response through pharmacologically reversible TGF-β2-dependent mechanisms.

Source: Cancers - May 18, 2020 Category: Cancer & Oncology Authors: Natalia Trempolec Charline Degavre Bastien Doix Davide Brusa Cyril Corbet Olivier Feron Tags: Article Source Type: research