Role of effector T  cells in multiple sclerosis

This figure entitled "Multiple factors affect the role of effector T  cells in MS" describes an image that effector T cells orchestrate the inflammation disrupting the myelin sheaths further leading to neurologic symptoms and multiple factors are associated with the role of effector T cells in MS. AbstractMultiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, and the imbalance between autoimmunity and immune tolerance is considered to be the key factor for its pathogenesis. Effector T  cells are shown to be involved not only in the early relapsing–remitting phase of this disease but also in the later progressive phase, which is thought to further promote the disease pathogenesis. Given the clinical benefits of the immune‐modulating reagents, which are designated as disease‐ modifying treatments, growing evidence has demonstrated their association with the amelioration of pathogenic T cells further suggesting their relevance in the treatment of MS, which is an immune‐mediated disease. T cells, a type of lymphocytes, play a central role in the immune response and hav e also been thought to play a pivotal role in MS. It has been well described that the effector CD4+ T cells, such as T helper (Th)1 and Th17 cells, orchestrate inflammation in the early phase including both infiltrating immune cells and brain‐resident glia cells and further disrupt the myelin she ath resulting in neurologic symptoms. Furthermore, recent reports hav...
Source: Clinical and Experimental Neuroimmunology - Category: Neurology Authors: Tags: REVIEW ARTICLE Source Type: research