Respiratory infections regulated blood cells IFN ‐β‐PD‐L1 pathway in pediatric asthma

Conclusions and Clinical RelevanceThese data indicate that, in the presence of infection in the airways of preschool children, worse asthma is associated with inducedPD ‐L1 mRNA expression in blood cells. Further, type I IFN, IFN ‐β, a cytokine that is involved in the clearance of infections, was found to be associated with a better lung function in asthmatic children. These data suggest that improving peripheral blood IFN type I expression in PBMCs in pediatric asthma could improve disease exacerbation due to suppressing PD‐L1 expression in blood cells.

Source: Immunity, Inflammation and Disease - May 11, 2020 Category: Allergy & Immunology Authors: Julia K ölle, Patricia Haag, Tytti Vuorinen, Kiefer Alexander, Manfred Rauh, Theodor Zimmermann, Nikolaos G. Papadopoulos, Susetta Finotto Tags: ORIGINAL RESEARCH Source Type: research