Relation between intra-mitochondrial inclusions and pathophysiology of mitochondrial myopathy remains unprecise

with interest we read the article by Lu et al. about a study on the frequency of intra-mitochondrial lipofuscin aggregates (IMLAs), spherical dense bodies (SDBs), and paracristalline inclusions (PCIs) in 24 patients with mitochondrial myopathy on histopathology or progressive external ophthalmoplegia (PEO) on clinical examination, 10 patients with inclusion body myopathy (IBM), and 21 young respectively old patients with minimal myopathic changes [1]. IMLAs were more frequent in old compared to young patients with minimal myopathic changes [1].
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Letter to the Editor Source Type: research