O-GlcNAcylation under hypoxic conditions and its effects on the blood-retinal barrier in diabetic retinopathy.

In conclusion, the current study demonstrates the relationship between O-GlcNAc glycosylation and hypoxia during diabetic retinopathy and that hyperglycemia induced O2 consumption activates HIF1α and O-GlcNAc modification protein in the same retinal layer. The reduced protein BRVEC O-GlcNAcylation levels exert protective effects on the blood-retinal barrier and thus represent a potential therapeutic target for the treatment of diabetic retinopathy.
PMID: 24366041 [PubMed - as supplied by publisher]

Source: International Journal of Molecular Medicine - December 20, 2013 Category: Molecular Biology Authors: Xu C, Liu G, Liu X, Wang F Tags: Int J Mol Med Source Type: research