Serum Levels of Alpha Fetoprotein Increased More Than 10 Years Before Detection of Hepatocellular Carcinoma.
Ultrasound (US)-based screening has been recommended for patients with an increased risk of hepatocellular Carcinoma (HCC). US analysis is, however, limited in patients who are obese or have small tumors. Addition of measurement of serum level of alpha-fetoprotein (AFP) to US analysis can increase detection of HCC. We analyzed data from patients with chronic liver disease, collected over 15 years in an HCC surveillance program, to develop a model to assess risk of HCC.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: David M. Hughes, Sarah Berhane, C.A. Emily de Groot, Hidenori Toyoda, Toshifumi Tada, Takashi Kumada, Shinji Satomura, Naoshi Nishida, Masatoshi Kudo, Toru Kimura, Yukio Osaki, Ruwanthi Kolamunage-Dona, Ruben Amoros Salvador, Tom Bird, Marta Garc ίa-Fià Source Type: research