Detection of autoantibodies against alpha-2-macroglobulin-like 1 in paraneoplastic pemphigus sera utilizing novel green fluorescent protein-based immunoassays

Paraneoplastic pemphigus (PNP), also termed paraneoplastic autoimmune multi-organ syndrome (PAMS), is a severe autoimmune blistering disease of the skin and mucosae associated with an underlying neoplasia. PNP patients have circulating autoantibodies binding to components of stratified as well as non-stratified epithelia [1,2,3]. Specifically, PNP autoantibodies typically bind to members of the plakin family of proteins, including envoplakin, periplakin, desmoplakin, and, more rarely, the bullous pemphigoid antigen 230 and plectin [1,4 –14].
Source: Journal of Dermatological Science - Category: Dermatology Authors: Source Type: research