Transforaminal and systemic diffusion of an active agent from a zinc oxide eugenol-based endodontic sealer containing hydrocortisone —in an in vivo model

ConclusionsThis study demonstrated that radioactive-HCA from Endomethasone N can diffuse through the apex of the root canal and follow a classical pharmacokinetics.Clinical relevanceThis mouse model shows that radioactive-HCA can diffuse through the apex and do not accumulate in periapical-like tissues and organs.

http://link.springer.com/10.1007/s00784-020-03305-5

Source: Clinical Oral Investigations - May 7, 2020 Category: Dentistry Source Type: research