Ampicillin Treatment Increases Placental Interleukin-1 Beta Concentration and Polymorphonuclear Infiltration in Group B Streptococcus-Induced Chorioamnionitis: A Preclinical Study.

CONCLUSIONS: Ampicillin increases placental inflammation in a rat model of GBS-induced chorioamnionitis without bacteremia. This proinflammatory effect of ampicillin could be due to bacterial lysis. Our findings do not query the intrapartum antibiotic prophylaxis against GBS disease. They pave the way for future preclinical studies combining anti-inflammatory treatments and antibiotic therapy for GBS-induced chorioamnionitis. PMID: 32375156 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32375156?dopt=Abstract

Source: Neonatology - May 5, 2020 Category: Perinatology & Neonatology Authors: Giraud A, Allard MJ, Segura M, Roche F, Patural H, Sébire G Tags: Neonatology Source Type: research