Elevated pigment epithelium-derived factor induces diabetic erectile dysfunction via interruption of the Akt/Hsp90 β/eNOS complex

Conclusions/interpretationThese results indicate that elevated PEDF levels contribute to impaired erectile function by suppressing Hsp90 β-mediated eNOS phosphorylation and that PEDF may represent a novel therapeutic target for diabetic erectile dysfunction.Graphical abstract
Source: Diabetologia - Category: Endocrinology Source Type: research