Ultrasensitive RT-QuIC assay with high sensitivity and specificity for Lewy body-associated synucleinopathies

In conclusion, α-synuclein RT-QuIC provides an accurate marker of synucleinopathies linked to LB pa thology and may have a pivotal role in the early discrimination and management of affected patients. The finding of no α-synuclein seeding activity in MSA seems to support the current view that MSA and LBD are associated with different conformational strains of α-synuclein.
Source: Acta Neuropathologica - Category: Neurology Source Type: research