Aiming at ideal therapeutics- MOPr/DOPr or MOPr-DOPr heteromer-targeting ligand.

CONCLUSION: I found that most of those ligands possesses potent antinociceptive activity (as much as or higher than that of morphine) with reduced side effects such as tolerance. In addition, some of them are also able to reduce or prevent physiological withdrawal symptoms observed under chronic opioid use. Importantly, there are increasing number of evidences that show changes in heteromer expression in various pathological animal models and these strongly argue for targeting heteromers for the development the next generation of pain medication in the near future. PMID: 32324516 [PubMed - as supplied by publisher]
Source: Current Topics in Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Top Med Chem Source Type: research