Toxic epidermal necrolysis accompanied by several immune-related adverse events developed after discontinuation of nivolumab

Common cutaneous events, such as lichenoid reactions and vitiligo, induced by immune checkpoint inhibitors (ICs) are typically of low grade, while toxic epidermal necrolysis (TEN) as an immune-related adverse event (irAE) is quite rare. However, gene expression profile of lesional skin from anti –programmed cell death-1 (PD-1)–related cutaneous AEs resembled Stevens-Johnson syndrome (SJS)/TEN-like pattern [1], suggesting that anti–PD-1 antibody could induce SJS/TEN-like reactions at least in some patients and it should be considered during treatment with ICs.

Source: European Journal of Cancer - April 1, 2020 Category: Cancer & Oncology Authors: Yuko Watanabe, Yukie Yamaguchi, Naoko Takamura, Yukitoshi Takahashi, Michiko Aihara Tags: Letter to the Editor Source Type: research