Animal models to understand the etiology and pathophysiology of polycystic ovary syndrome.

Animal models to understand the etiology and pathophysiology of polycystic ovary syndrome. Endocr Rev. 2020 Apr 20;: Authors: Stener-Victorin E, Padmanabhan V, Walters KA, Campbell RE, Benrick A, Giacobini P, Dumesic DA, Abbott DH Abstract More than one out of ten women worldwide are diagnosed with the leading cause of female reproductive and metabolic dysfunction, polycystic ovary syndrome (PCOS). Despite its high prevalence, PCOS and its accompanying morbidities are likely under-diagnosed, averaging >2 years and 3 physicians before women are diagnosed. Although it has been intensively researched, the underlying cause(s) of PCOS have yet to be defined. In order to understand PCOS pathophysiology, its developmental origins, and how to predict and prevent PCOS onset, there is urgent need for safe and effective markers and treatments. In this review, we detail which animal models are more suitable for contributing to our understanding of the etiology and pathophysiology of PCOS. We summarize and highlight advantages and limitations of hormonal or genetic manipulation of animal models, as well as of naturally occurring PCOS-like females. PMID: 32310267 [PubMed - as supplied by publisher]
Source: Endocrine Reviews - Category: Endocrinology Tags: Endocr Rev Source Type: research