α-Synucleinopathy associated c-Abl activation causes p53-dependent autophagy impairment

Studies link c-Abl activation with the accumulation of pathogenic α-synuclein (αS) and neurodegeneration in Parkinson’s disease (PD). Currently, c-Abl, a tyrosine kinase activated by cellular stress, is though...

Source: Molecular Neurodegeneration - April 16, 2020 Category: Neurology Authors: Md. Razaul Karim, Elly E. Liao, Jaekwang Kim, Joyce Meints, Hector Martell Martinez, Olga Pletnikova, Juan C. Troncoso and Michael K. Lee Tags: Research article Source Type: research