Plasmodium vivax in Hematopoietic Niches: Hidden and Dangerous.

Plasmodium vivax in Hematopoietic Niches: Hidden and Dangerous. Trends Parasitol. 2020 May;36(5):447-458 Authors: Silva-Filho JL, Lacerda MVG, Recker M, Wassmer SC, Marti M, Costa FTM Abstract Estimation of Plasmodium vivax biomass based on circulating biomarkers indicates the existence of a predominant biomass outside of the circulation that is not captured by peripheral parasitemia, in particular in patients with complicated outcomes. A series of recent studies have suggested that the hematopoietic niche of the bone marrow (BM) is a major reservoir for parasite replication and the development of transmission stages. However, significant knowledge gaps remain in our understanding of host-parasite interactions, pathophysiology, and the implications for treatment and diagnosis of such a reservoir. Here, we discuss the current status of this emerging research field in the context of P. vivax. PMID: 32298632 [PubMed - in process]
Source: Trends in Parasitology - Category: Parasitology Authors: Tags: Trends Parasitol Source Type: research