Quassilactones A and B, structural characterization of a new class of norquassinoids from Brucea javanica

AbstractTwo novel norquassinoids possessing a unique ketal skeleton, designated quassilactones A (1) and B (2), were isolated from the fruits ofBrucea javanica (Simaroubaceae). Their structures were established by extensive NMR and HR-ESI-MS spectroscopic analysis. The absolute configuration of1 was determined through single-crystal X-ray crystallography, and that of2 was assigned by comparing the calculated electronic and experimental circular dichroism with compound1. In addition, their cytotoxic activities against three human cancer cell lines and their antimicrobial activities were evaluated.Graphic abstract
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research