Comparable Effect of Two-Step Versus Extended Infusions on the Pharmacokinetics of Imipenem in Patients with Sepsis and Septic Shock
ConclusionThe two-step and extended regimens of imipenem are comparable to the PK/PD target in the treatment of sepsis and septic shock. A higher dose (1.0 gq8h) should be considered for target achievement at an MIC of > 8 μg/ml.Trial RegistrationClinicalTrials.gov identifier, NCT02616354.
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research