Pushing Cherenkov PET with BGO via coincidence time resolution classification and correction.

Pushing Cherenkov PET with BGO via coincidence time resolution classification and correction.
Phys Med Biol. 2020 Apr 08;:
Authors: Kratochwil N, Gundacker S, Lecoq P, Auffray E
Abstract
Bismuth germanate (BGO) shows good properties for PET applications, but was substituted by the development of faster crystals like Lutetium oxyorthosilicate (LSO) for time-of-flight PET (TOF-PET). Recent improvements in silicon photomultipliers (SiPM) and fast readout electronics make it possible to access the Cherenkov photon signal produced upon 511 keV interaction, which makes BGO a cost effective candidate for TOF-PET. Tails in the time delay distribution, however, remain a challenge. These are mainly caused by the high statistical fluctuation on the Cherenkov photons detected. To select fast events with a high detected Cherenkov photon number, the signal rise time of the SiPM was used for discrimination. The charge, time delay and signal rise time was measured for two different lengths of BGO crystals coupled to FBK NUV-HD SiPM and high frequency readout in a coincidence time resolution setup. The recorded events were divided into 5x5 categories based on the signal rise time and a time resolution of 200 ± 3 ps for 2×2×20 mm 3 and 117 ± 3 ps for 2×2×3 mm 3 was measured for the fastest 20% of the events (4% in coincidence). These good timing events can bring additional information in the image reconstruction in order to increase the SNR sign...

Source: Physics in Medicine and Biology - April 7, 2020 Category: Physics Authors: Kratochwil N, Gundacker S, Lecoq P, Auffray E Tags: Phys Med Biol Source Type: research