“Aspirin Resistance” in Ischemic Stroke: Insights Using Short Thrombelastography

Conclusion: This study demonstrates that although COX-1 activity is adequately and consistently suppressed by aspirin in stroke patients, this effect is not reliably indicated by whole-blood clotting in response to AA. These data help to explain why the reported prevalence of aspirin resistance in stroke from studies employing AA-induced platelet reactivity is high and cast doubt on the veracity of such reports.

Source: Journal of Stroke and Cerebrovascular Diseases - July 8, 2013 Category: Neurology Authors: Nalyaka Sambu, Ashwin Radhakrishnan, Nicola Englyst, Nicolas Weir, Nick Curzen Tags: Original Articles Source Type: research