Effects of the Experimental Subarachnoid Hemorrhage on the Eicosanoid Receptors in Nicotine-induced Contraction of the Rat Basilar Artery

Conclusions: BLT2 receptor seemed to be more involved in the nicotine-induced contraction than the BLT1 receptor. SAH did not affect the involvement of eicosanoids in the nicotine-induced contraction of the rat basilar artery. The present study shows the involvement of some of the arachidonic acid metabolites into signaling pathways of nicotine-induced contraction. It will serve to improve therapeutic interventions of SAH and suggests a promising approach to protect the cerebral vasculature of cigarette smokers.
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Tags: Original Articles Source Type: research