Beyond Crohn Disease

This article discusses the role of imaging in evaluation of IBD transitioning from pediatric to adult patients. Imaging modalities and techniques used for evaluating IBD are reviewed. Characteristic acute and chronic imaging findings of IBD are discussed with emphasis on what radiologists need to clearly understand.
Source: Radiologic Clinics of North America - Category: Radiology Authors: Source Type: research

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Contributors : Fatemeh Adiliaghdam ; Sreehaas Digumarthi ; Lai P Wong ; Ruslan Sadreyev ; Kate L JeffreySeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensPeripheral blood-derived macrophages were stimulated with viral-like particles isolated from colonic resections from patients with Crohn's disease (CD), ulcerative colitis (UC), or non-IBD controls diagnoses. RNAseq was performed to unbiasedly assess the transcriptional responses to these stimuli and revealed highly divergent macrophage transcriptional programs in response to non-IBD compared to IBD VLP.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Publication date: Available online 30 May 2020Source: European Journal of RadiologyAuthor(s): L. Tkalčić, Kaštelan Z. Matana, T. Grubešić, Sinčić B. Mijandrušić, S. Milić, D. Miletić
Source: European Journal of Radiology - Category: Radiology Source Type: research
A 42-year-old woman presented with a 3-week history of left hand swelling and pain, with a “shooting” sensation up her arm. Medical history was remarkable for Crohn disease on adalimumab and azathioprine. Physical examination was notable for erythema and tenderness on the palmar aspect of the left hand (Figure 1). Magnetic resonance imaging (MRI) identified flexor tenosynovial enhanc ement with surrounding inflammation (Supplemental Figure 1, available online at http://www.mayoclinicproceedings.org).
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Medical image Source Type: research
AbstractCrohn ’s disease (CD) is a type of inflammatory bowel disease (IBD) and affects diverse segments of the entire gastrointestinal tract. Although the underlying causes of CD are not completely known, it is believed that disruption of the intestinal barrier and cell polarity may contribute to pathogenesis. The formation of the intestinal epithelial barrier, which is mainly regulated by cytoskeletal modulations, and apico-basal cell polarity are two major and mutually dependent features of the intestinal epithelial layer. As this layer serves as an important barrier between the external environment an d the inter...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
Conclusion: To our knowledge, this is the first report of successful use of anti-TNF-α therapy for a patient with granulomatous hypophysitis, in this case associated with a previous diagnosis of CD. Although glucocorticoids are used frequently as first-line therapy for primary hypophysitis, granulomatous hypophysitis can be corticosteroid resistant and other immunosuppressive approaches may need to be considered within the context of the patient.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
In their recent publication Assan et  al1 have shown that both IgG and IgA anti–Saccharomyces cerevisiae antibodies (ASCAs) are associated with hidradenitis suppurativa (HS).1 As the authors state, ASCA positivity has long been associated with Crohn disease and has recently been identified as a biomarker for spondyloarthritis (SpA). However, both Crohn disease and SpA comprise distinct phenotypes. The phenotype in Crohn disease can change from an inflammatory phenotype, to a fibrostenotic or penetrating phenotype with respectively severe stricturing or fistulation.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Correspondence Source Type: research
Conclusion: Lnc-ITSN1-2 correlates with increased disease risk, activity, and inflammatory cytokines of IBD, and promotes IBD CD4+ T cell activation, proliferation, and Th1/Th17 cell differentiation by serving as a competing endogenous RNA for IL-23R via sponging miR-125a.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
CONCLUSION: Baseline characteristics and outcomes of patients with IBD-IgAV are similar to those with IgAV without IBD. Development of IgAV is not limited to patients with clinically active IBD. Whether TNFi use is related to the pathogenesis of IgAV in some patients with IBD remains unclear. Further research into pathophysiological connections between IBD and IgAV is needed. PMID: 32456601 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Rheumatology - Category: Rheumatology Authors: Tags: Scand J Rheumatol Source Type: research
The peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that promote ligand-dependent transcription of target genes that regulate energy production, lipid metabolism, and inflammation. The PPAR superfamily comprises three subtypes, PPARα, PPARγ, and PPARβ/δ, with differential tissue distributions. In addition to their different roles in the regulation of energy balance and carbohydrate and lipid metabolism, an emerging function of PPARs includes normal homeostasis of intestinal tissue. PPARα activation represses NF-κB signaling, which decreases the...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
eacute;n O Abstract BACKGROUND: Treatment of patients with Crohn's disease has evolved in recent decades, with increasing use of immunomodulatory medication since 1990 and biologicals since 1998. In parallel, there has been increased use of active disease monitoring. To what extent these changes have influenced the incidence of primary and repeat surgical resection remains debated. METHODS: In this nationwide cohort study, incident patients of all ages with Crohn's disease, identified in Swedish National Patient Registry between 1990 and 2014, were divided into five calendar periods of diagnosis: 1990-1995 an...
Source: The British Journal of Surgery - Category: Surgery Authors: Tags: Br J Surg Source Type: research
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