Quantitative Measure of Asymptomatic Cardiovascular Disease Risk in Type-2 Diabetes (MARK): Evidence from Indian Outpatient Setting

Publication date: Available online 6 April 2020Source: Indian Heart JournalAuthor(s): Samit Ghosal, Binayak Sinha, Jignesh Ved, Mansij Biswas
Source: Indian Heart Journal - Category: Cardiology Source Type: research

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CONCLUSION: SHED combined with HBO therapy was effective for treating type 2 diabetic rats. The underlying mechanism may involve SHED-mediated increase in the proliferation and trans-differentiation of islet β -cells and decrease in pro-inflammatory cytokines and apoptosis of islets.
Source: Clinics - Category: General Medicine Source Type: research
Publication date: Available online 2 June 2020Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Amerta Ghosh, Bhavya Arora, Ritesh Gupta, Shajith Anoop, Anoop Misra
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
Publication date: Available online 21 March 2020Source: Canadian Journal of DiabetesAuthor(s): Chantal L. Lemieux, Margaret deGroh, Laurie Gibbons, Howard Morrison, Ying Jiang
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
Fractyl Laboratories is seeking to ‘turn back the clock’ in Type 2 diabetes progression with its disease-modifying therapy. FDA granted the Lexington, MA-based company IDE to launch a pivotal trial of the Revita DMR, a which holds the potential to eliminate the need for insulin injections in patients suffering from Type 2 diabetes. “Insulin is a challenging drug for patients with Type 2 diabetes because it can cause weight gain,” Harith Rajagopalan M.D. Ph.D., co-founder and CEO of Fractyl told MD+DI. “It can cause a risk of your bloo...
Source: MDDI - Category: Medical Devices Authors: Tags: Implants Regulatory and Compliance Source Type: news
Authors: Zhang C, Cai W, Zhao H, Zhu M, Cui J, Sun Z Abstract To compare the clinical efficacy of gastric bypass in obese patients with T2DM with different BMI. Serum leptin, adiponectin, triglyceride (TG), cholesterol (CHOL) were measured as the indicators to show clinical efficacy after laparoscopic gastric bypass surgery (LRYGB). For patients with high BMI and patients with low BMI, the therapeutic effect of LRYGB surgical diabetes is more significant. The postoperative remission rate of diabetes in the high BMI group was not correlated with the preoperative lipid metabolism index but was positively correlated w...
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
Abstract The extract of Lycium bark (LBE), which is the root bark of Lycium chinense, has long been used in China for hypertension, inflammation, and diabetes. LBE has been reported to ameliorate hyperglycemia in mice with alloxan-induced type 1 diabetes, but evidence on the effect of LBE in diabetes had not been enough. Therefore, we investigated the effects of LBE on type 2 diabetes using db/db mice. Nine-week-old male db/db mice were orally administered LBE (425 mg/kg) for 10 weeks. Blood samples were collected under anesthesia for the determination of blood glucose and insulin levels. The blood glucose ...
Source: Biological and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Biol Pharm Bull Source Type: research
TYPE 2 diabetes is a common condition which causes a person's blood sugar levels to become too high, and left untreated serious complications can develop. To avoid these complications, spotting symptoms of the condition is important, and one sign to watch out for is in the hands.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Epidemiologic studies using electronic health record (EHR)-derived phenotypes as outcomes are subject to bias due to phenotyping error. In the case of dichotomous phenotypes, existing methods for misclassified outcomes can be used to reduce bias. In this article, we present a bias correction approach for EHR-derived probabilistic phenotypes: continuous predicted probabilities of the outcome of interest. This approach makes use of correction factors that can be computed by hand and do not require specialized software. We used simulation studies to investigate the performance of the proposed approach under a variety of scena...
Source: Epidemiology - Category: Epidemiology Tags: Methods Source Type: research
Conclusions: In this population-based study, the detection of breast cancer gradually increased with GLP-1 RA weight loss categories, particularly among those achieving>10% weight loss. These results are consistent with the hypothesis that substantial weight loss with GLP-1 RAs may improve detection of breast cancer among obese patients with type 2 diabetes.
Source: Epidemiology - Category: Epidemiology Tags: Pharmacoepidemiology Source Type: research
Some things you may need to know.  Nothing last week as I was " on holiday " , so two weeks'worth this time.COVID-19A systematic scoping review of COVID-19 during pregnancy and childbirth (International Journal of Obstetrics and Gynecology)ResearchProgression to type 2 diabetes in women with a known history of gestational diabetes: systematic review and meta-analysis (BMJ)**Leicester authors**Comparative impact of pharmacological treatments for gestational diabetes on neonatal anthropometry independent of maternal glycaemic control: A systematic review and meta-analysis (PLoS Medicine)Maternal cardiovas...
Source: Browsing - Category: Databases & Libraries Tags: midwifery Source Type: blogs
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