Corneal pharmacokinetics of voriconazole and posaconazole following intrastromal injection and posaconazole eye drops instillation in rats.

Conclusion: Our results show that there is little interest of intrastromal triazole administration due to the short duration of high cornea concentrations obtained after intracorneal injection. Posaconazole eye drops maintain therapeutic cornea concentrations in rats and could be used to treat severe infectious keratitis.
PMID: 32228098 [PubMed - as supplied by publisher]

Source: Current Eye Research - March 29, 2020 Category: Opthalmology Authors: Gueudry J, Le Goff L, Lamoureux F, Pereira T, Levefre S, Razakandrainibe R, Costa D, Ballet JJ, Muraine M, Favennec L Tags: Curr Eye Res Source Type: research