Transcranial focused ultrasound, pulsed at 40 Hz, activates microglia acutely and reduces A β load, chronically, as demonstrated in vivo

Iaccarino et al [1] exposed one hour of light flickering at 40 Hz to awake 5XFAD Alzheimer ’s Disease (AD) mouse models, generating action potentials at 40 Hz, activating ∼54% of microglia to colocalize with Aβ plaque, acutely, and clearing ∼ 50% of Aβ plaque after seven days, but only in the visual cortex.

Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - March 31, 2020 Category: Neurology Authors: M.S. Bobola, L. Chen, C.K. Ezeokeke, T.A. Olmstead, C. Nguyen, A. Sahota, R.G. Williams, P.D. Mourad Source Type: research