Tandem P-selectin glycoprotein ligand immunoglobulin (TSGL-Ig) prevents lung vaso-occlusion in Sickle Cell Disease mice

Sickle cell anemia, the most common form of sickle cell disease (SCD) is caused by the homozygous mutation in the β-globin gene, which leads to erythrocyte sickling, impaired rheology, vaso-occlusion and premature hemolysis6. Vaso-occlusion and hemolysis are the two predominant pathophysiological events in SCD that contribute to chronic organ damage and acute systemic painful vaso-occlusive episode (VOE)3,6. E arlier, we have shown that VOE involves entrapment of large neutrophil-platelet aggregates in lung arterioles of SCD mice, which is inhibited following IV administration of P-selectin function blocking antibody5.

Source: Experimental Hematology - March 30, 2020 Category: Hematology Authors: Ravi Vats, Egemen Tutuncuoglu, Tirthadipa Pradhan-Sundd, Jesus Tejero, Gray D. Shaw, Prithu Sundd Tags: Brief Communication Source Type: research