Homing of Multipotent Mesenchymal Stromal Cells with Different Administration Routes in Old Laboratory Animals after Liver Resection

AbstractThe purpose of this research was to study the migration of multipotent mesenchymal stromal cells (MMSCs) in old laboratory animals under physiological conditions and after liver resection. In this case, different administration routes were used: in the tail vein; intraperitoneally; in the hepatic artery; and in the portal vein. Studies indicate an old body is able to respond with changes in the directed migration of MMSCs to the tissues subjected to the greatest damage. This may result from the production of a chemoattractant by the connective tissue of the damaged organ. In contrast to intraperitoneal injection, other methods of MMSC delivery (to the tail vein,v. portae, anda. hepatica) are the most efficient.
Source: Advances in Gerontology - Category: Geriatrics Source Type: research