Differences in Age at Onset of Symptoms, and Effects of Genetic Variants, in Patients With Early- vs Late-Onset Idiopathic Chronic Pancreatitis in a North American Cohort

Idiopathic chronic pancreatitis (ICP) is the second most common subtype of CP. In 1994, researchers reported the bimodal age at onset of ICP symptoms: early-onset ICP (EO-ICP; median age, 19.2 years) and late-onset ICP (LO-ICP; median age, 56.2 years). Ages of onset and clinical features of ICP differed from those of alcohol-related CP (ACP). However, variants in PRSS1 had not yet been associated with ICP. We reexamined ages of onset of ICP in a large, North American cohort of patients, and investigated the effects of genetic factors and alcohol use in patients with EO-ICP, LO-ICP, or ACP.

Source: Clinical Gastroenterology and Hepatology - March 31, 2020 Category: Gastroenterology Authors: Michele D. Lewis, Jyothsna Talluri, C. Mel Wilcox, Judah N. Abberbock, Gong Tang, Darwin L. Conwell, Peter A. Banks, Gregory A. Cote, Stuart Sherman, Samer Alkaade, Timothy B. Gardner, Michelle A. Anderson, Bimaljit S. Sandhu, Thiruvengadam Muniraj, Chris Source Type: research