Developmental exposure to Δ 9 -tetrahydrocannabinol (THC) causes biphasic effects on longevity, inflammation, and reproduction in aged zebrafish ( Danio rerio )

In this study, zebrafish (Danio rerio) were exposed to different concentrations of THC (0.08, 0.4, 2  μM) during embryonic-larval development and the effects on aging were measured 30 months later and in the offspring of the exposed fish (F1 generation). Exposure to 0.08 μM THC resulted in increased male survival at 30 months of age. As the concentration of THC increased, this protective effe ct was lost. Treatment with the lowest concentration of THC also significantly increased egg production, while higher concentrations resulted in impaired fecundity. Treatment with the lowest dose of THC significantly reduced wet weight, the incidence of kyphosis, and the expression of several senesc ence and inflammatory markers (p16ink4ab,tnf α,il-1 β,il-6, ppar α andppar γ) in the liver, but not at higher doses indicating a biphasic or hormetic effect. Exposure to THC did not affect the age-related reductions in locomotor behavior. Within the F1 generation, many of these changes were not observed. However, the reduction in fecundity due to THC exposure was worse in the F1 generation because offspring whose parents received high dose of THC were completely unable to reproduce. Together, our results demonstrate that a developmental exposure to THC can cause significant effects on longevity and healthspan of zebrafish in a biphasic manner.
Source: AGE - Category: Geriatrics Source Type: research

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Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
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Source: European Spine Journal - Category: Orthopaedics Source Type: research
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Conditions:   Degenerative Disc Disease;   Degenerative Spondylolisthesis;   Degenerative Scoliosis Intervention:   Sponsor:   NuVasive Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Degenerative Disc Disease;   Degenerative Spondylolisthesis;   Degenerative Scoliosis Intervention:   Sponsor:   NuVasive Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Degenerative Disc Disease;   Degenerative Spondylolisthesis;   Degenerative Scoliosis Intervention:   Sponsor:   NuVasive Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Degenerative Disc Disease;   Degenerative Spondylolisthesis;   Degenerative Scoliosis Intervention:   Sponsor:   NuVasive Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Journal of Craniovertebral Junction and Spine - Category: Orthopaedics Authors: Source Type: research
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Source: Journal of Craniovertebral Junction and Spine - Category: Orthopaedics Authors: Source Type: research
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