Sleep disturbances in Italian children and adolescents with epilepsy: A questionnaire study

Publication date: May 2020Source: Epilepsy &Behavior, Volume 106Author(s): Elena Zambrelli, Katherine Turner, Aglaia Vignoli, Francesca La Briola, Silvia Dionisio, Sara Malanchini, Federica Galli, Maria Paola Canevini
Source: Epilepsy and Behavior - Category: Neurology Source Type: research

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Conclusion: The current analysis methods are prone to biases. A common agreement on a standard operating procedure is needed to ensure reliable and economic detection of high-frequency oscillations.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
The prevalence of epilepsy is between 4 and 10 per 1000 in the developed world, similar between men and women [1]; therefore, epilepsy is one of the most common chronic neurologic conditions affecting women of child-bearing age. While many women with epilepsy experience no change in seizure frequency during pregnancy, up to one-third of women have an increase in seizure frequency [2]. These increases are likely mediated by multiple factors including changes in ASD (anti-seizure drug) metabolism, changes in hormone levels, medication compliance, and sleep deprivation.
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Source Type: research
The objective of this study was to gain a better understanding of parental hopes and worries before and subsequent experiences two years after their child had undergone epilepsy surgery. METHODS: The parents of 107 children and young people who underwent epilepsy surgery at a single center completed surveys focusing on hopes and concerns before surgery and subsequent experiences at two-year follow-up. Responses were analyzed by thematic analysis. RESULTS: Before surgery, parental hopes focus on not only seizure freedom or reduction but also potential improvements in child development and emotional-behavioral func...
Source: Epilepsy and Behaviour - Category: Neurology Authors: Tags: Epilepsy Behav Source Type: research
CONCLUSIONS: Early morning peaks of autostimulations at low thresholds may reflect awakening-induced activation of the cardiovascular system, which is associated with a shift towards the dominance of the sympathetic branch of the autonomic nervous system. Cortisol release occurs in parallel driven by wakening-induced activation of the hypothalamic-pituitary-adrenal axis, which is fine-tuned by direct sympathetic input to the adrenal gland. This is of interest considering the known sympathetic hyperactivity in patients with epilepsy. PMID: 32473521 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - Category: Neurology Authors: Tags: Epilepsy Behav Source Type: research
Spinocerebellar ataxia type 10 (SCA10), one of the autosomal dominant ataxias, is characterized by slowly progressive gait ataxia, dysarthria, nystagmus, epilepsy as well as non-motor symptoms [1]. The latter include dysautonomia, cognitive deficits, chronic pain, psychiatric comorbidities and sleep disorders [ [1,2]]. SCA10 is caused by expansion of ATTCT pentanucleotide repeats in the ATXN10 gene – which codes for ataxin 10 [ [1–3]]. Recent experimental data suggested a possible relationship between SCA10 and development of cancer [4].
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Tags: Correspondence Source Type: research
Authors: Nilo A, Gelisse P, Crespel A Abstract Genetic or idiopathic generalized epilepsies (IGEs) account for 15-20% of all epilepsies. These syndromes have always been considered as good prognosis forms of epilepsy over time; however, for some patients, there is a need to maintain antiseizure drugs (ASD) for a long-time. Drug resistance is not uncommon (7-15%). Lifestyle remains essential and is an integral part of the treatment. Comorbidities such as obstructive sleep apnea syndrome must be considered and treated. A highly underestimated condition is the risk of sudden unexpected death in epilepsy (SUDEP). Very ...
Source: Revue Neurologique - Category: Neurology Tags: Rev Neurol (Paris) Source Type: research
Conclusions: These results suggest that more needs to be done to raise awareness of the risks posed by medical and other factors that reduce driver capability and also about drivers' responsibility to ensure that they are fit to drive and thus improve road safety. PMID: 32421397 [PubMed - as supplied by publisher]
Source: Traffic Injury Prevention - Category: Accident Prevention Authors: Tags: Traffic Inj Prev Source Type: research
Growing evidence shows the bidirectional interactions between sleep, circadian rhythm, and epilepsy. Comprehending how these interact with each other may help to advance our understanding of the pathophysiology of epilepsy and develop new treatment strategies to improve seizure control by reducing the medication side effects and the risks associated with seizures. In this review, we present the overview of different temporal patterns of interictal epileptiform discharges and epileptic seizures over a period of 24 consecutive hours. Furthermore, we discuss the underlying mechanism of the core-clock gene in periodic seizure ...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
CONCLUSION: Methylprednisolone pulse therapy may be considered for possible treatment in patients with focal epilepsy with drug-resistant seizures without ES, and it may improve cognitive function and behavioral comorbidities. PMID: 32388139 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - Category: Neurology Authors: Tags: Epilepsy Behav Source Type: research
Authors: Hillis AE Abstract Introduction: Stroke is among the most common causes of disability worldwide. Nonmotor symptoms of stroke are common and disabling. Many are treatable, and intervention improves the quality of life for stroke survivors.Areas covered: Here the author summarizes evidence-based treatment of depression and other mood disorders, aphasia, hemispatial neglect, impairments of emotional communication and empathy, deficits in memory and other cognitive functions, sleep disorders, pain, fatigue, (1)and seizures resulting from stroke. The author focuses on treatments supported by randomized controlled ...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
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