Arabinofuranose ‐derived positron‐emission tomography radiotracers for detection of pathogenic microorganisms

CONCLUSIONS: Arabinofuranose ‐derived18F PET radiotracers can be synthesized with high radiochemical purity. Our study showed absence of bacterial accumulation for 5 ‐substitued analogs, a finding that may have mechanistic implications for related tracers. Bothd‐2‐18F ‐AF andl‐2‐18F ‐AF showed sensitivity to most gram‐negative and gram‐positive organisms. Future in vivo studies will evaluate the diagnostic accuracy of these radiotracers in animal models of infection.

Source: Journal of Labelled Compounds and Radiopharmaceuticals - March 29, 2020 Category: Biochemistry Authors: Mausam Kalita, Matthew F.L. Parker, Justin M. Luu, Megan N. Stewart, Joseph E. Blecha, Henry F. VanBrocklin, Michael J. Evans, Robert R. Flavell, Oren S. Rosenberg, Michael A. Ohliger, David M. Wilson Tags: RESEARCH ARTICLE Source Type: research