A Prospective Study: Connection Between Vitamin D Level and the Efficacy of Dexamethasone in Immune Thrombocytopenia

Condition:   Immune Thrombocytopenia Intervention:   Drug: Dexamethasone Sponsor:   Shandong University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Publication date: Available online 25 May 2020Source: The Lancet HaematologyAuthor(s): Wanxin Chen, Bohan Yang, Ziping Li, Ping Wang, Yan Chen, Hao Zhou
Source: The Lancet Haematology - Category: Hematology Source Type: research
AbstractTo review the efficacy and safety of glucocorticoids combined with different regimens for treating severe immune thrombocytopenia (ITP). Eighty-five severe ITP patients from 2 tertiary hospitals treated with glucocorticoids were enrolled from January 2018 to May 2019 and divided into 4 treatment groups: group A (treated with glucocorticoids), group B (glucocorticoids plus intravenous immunoglobulin (IVIg)), group C (glucocorticoids plus recombinant human thrombopoietin (rhTPO)), and group D (glucocorticoids plus IVIg and rhTPO). Statistical analysis was performed with SPSS 19.0 software. Early responses and respons...
Source: Clinical and Experimental Medicine - Category: Research Source Type: research
ABSTRACTStability analysis, often overlooked in pharmacometrics, is essential to explore dynamical systems. The model developed by Friberg1 to describe drug ‐induced haematotoxicity is widely used to support decisions across drug development, and parameter values are often identified from observed blood counts. We use stability analysis to study the parametric dependence of stable and unstable solutions of several Friberg‐type models, and highlight the risks associated with system instability in the context of non‐linear mixed effects modelling. We emphasize the consequences of unstable solutions on prediction perfor...
Source: CPT: Pharmacometrics and Systems Pharmacology - Category: Drugs & Pharmacology Authors: Tags: ARTICLE Source Type: research
Authors: Humbert S, Razanamahery J, Payet-Revest C, Bouiller K, Chirouze C PMID: 32445664 [PubMed - as supplied by publisher]
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
Pituitary apoplexy is a rare but life-threatening condition caused by sudden hemorrhage or infarction of the pituitary gland (1). The prevalence of this complication is approximately 8% in patients with preexisting nonfunctioning pituitary macroadenoma(2). It can result in rapid bilateral vision loss, altered mental status, panhypopituitarism, and increased intracranial pressure (3). Impaired coagulation status is one of the precipitating causes of pituitary apoplexy. Patients who undergo hematopoietic cell transplantation (HCT) develop significant thrombocytopenia, which puts them at higher risk for apoplexy (4).
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Case Report Source Type: research
Publication date: Available online 22 May 2020Source: Life SciencesAuthor(s): Seyedeh Sahar Mortazavi Farsani, Majid Sadeghizadeh, Mohammad Ali Gholampour, Zohreh Safari, Farhood Najafi
Source: Life Sciences - Category: Biology Source Type: research
Authors: Rath W, Tsikouras P, Stelzl P Abstract HELLP syndrome and the less common acute fatty liver of pregnancy (AFL) are unpredictable, life-threatening complications of pregnancy. The similarities in their clinical and laboratory presentations are often challenging for the obstetrician when making a differential diagnosis. Both diseases are characterised by microvesicular steatosis of varying degrees of severity. A specific risk profile does not exist for either of the entities. Genetic defects in mitochondrial fatty acid oxidation and multiple pregnancy are considered to be common predisposing factors. The dia...
Source: Geburtshilfe und Frauenheilkunde - Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research
This study examined whether the combination of hematological indices and FI can be used as an early diagnostic tool for NEC or sepsis. Study Design This retrospective cohort study included infants born at
Source: American Journal of Perinatology - Category: Perinatology & Neonatology Authors: Tags: Original Article Source Type: research
ConclusionsMost of the pregnant COVID ‐19 positive patients had a favorable clinical course. However, one‐third of them developed pneumonia, of whom 5% presented a critical clinical status. CRP and D‐dimer levels positively correlated with severe pneumonia and the neutrophil/lymphocyte ratio decreased as the patients improved clin ically. Seventy‐eight percent of patients had a vaginal delivery. No vertical or horizontal transmissions were diagnosed in the neonates during labor or breastfeeding.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
This study aimed to evaluate its effectiveness and safety of low ‐dose apatinib for the treatment of gastric cancer in real‐world practice. We performed a prospective, multicenter observation study in a real‐world setting. Patients with advanced gastric cancer more than 18 years old were eligible and received low‐dose apatinib (500 mg or 250mg per day) therapy. The median progression‐free survival (PFS), median overall survival (OS), objective response rate (ORR), disease control rate (DCR), and safety were assessed. Between September 2017 and April 2019, a total of 747 patients were enrolled. The mPFS ...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
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