The role of eosinophils in chronic spontaneous urticaria

Chronic spontaneous urticaria (CSU) is considered to be primarily a mast cell-driven disease. However, recent evidence suggests that eosinophils may also have an axial role in symptomology. Histological studies have demonstrated the presence of both eosinophils and eosinophil granules, indicative of activation, in CSU lesions. While many allergic and inflammatory conditions are associated with a peripheral blood eosinophilia, the converse appears to be the case in CSU, a peripheral blood eosinopenia being observed in many patients.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research