Multi-perspective clustering of obstructive sleep apnea towards precision therapeutic decision including craniofacial intervention

ConclusionsThe three OSA phenotypes from multi-perspective clustering may provide a basis for precise therapeutic decision-making including craniofacial skeletal intervention beyond usual characterization of OSA subgroups.
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research

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This study aims to determine if SCZ patients are at increased risk of incident OSA.MethodsA total of 5092 newly diagnosed SCZ patients and 5092 non-SCZ controls matched by gender, age, and index year were included between 2000 and 2012 and followed to 2013. Participants newly diagnosed with OSA were defined as incidents. Cox regression analysis was used to calculate the hazard ratio (HR) with 95% confidence intervals (CI) of the OSA incidence rate between the two groups studied.ResultsSCZ patients were at increased risk of OSA compared to non-SCZ controls after adjusting for gender, age, comorbidities, and duration of anti...
Source: Social Psychiatry and Psychiatric Epidemiology - Category: Psychiatry Source Type: research
Conclusion: The relationship between snoring and obesity has not been well explored. This study among slum-dwelling Indian women found a significant relationship between snoring and obesity. Future research should explore the underlying mechanisms connecting snoring to BMI.
Source: Lung India - Category: Respiratory Medicine Authors: Source Type: research
Genes, Vol. 11, Pages 461: An Integrative Phenotype–Genotype Approach Using Phenotypic Characteristics from the UAE National Diabetes Study Identifies HSD17B12 as a Candidate Gene for Obesity and Type 2 Diabetes Genes doi: 10.3390/genes11040461 Authors: Mahmood Y. Hachim Hayat Aljaibeji Rifat A. Hamoudi Ibrahim Y. Hachim Noha M. Elemam Abdul Khader Mohammed Albert Salehi Jalal Taneera Nabil Sulaiman The United Arab Emirates National Diabetes and Lifestyle Study (UAEDIAB) has identified obesity, hypertension, obstructive sleep apnea, and dyslipidemia as common phenotypic characteristics correlate...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
ConclusionsSG was the preferable option to RYGB for patients aged 60  years old or older, as SG has been shown not inferior to RYGB in terms of effectiveness, while being safer than RYGB.
Source: Obesity Surgery - Category: Surgery Source Type: research
CONCLUSIONS: The three OSA phenotypes from multi-perspective clustering may provide a basis for precise therapeutic decision-making including craniofacial skeletal intervention beyond usual characterization of OSA subgroups. PMID: 32219710 [PubMed - as supplied by publisher]
Source: Sleep and Breathing - Category: Sleep Medicine Authors: Tags: Sleep Breath Source Type: research
This study included patients who underwent primary laparoscopic Roux-en-Y gastric bypass (LRYGB) or laparoscopic sleeve gastrectomy (LSG). The primary outcome of interest was incisional SSI occurring within 30  days. Surgeries performed in 2015 were used in a derivation cohort and the predictive tool was validated against the 2016 cohort. A forward selection algorithm was used to build a logistic regression model predicting probability of SSI.ResultsA total of 274,187 patients were included with 71.7% being LSG and 28.3% LRYGB. 0.7% of patients had a SSI in which 71.0% had an incisional SSI, and 29.9% had an organ/spa...
Source: Surgical Endoscopy - Category: Surgery Source Type: research
Conclusions: The LSG is an effective method of treatment in all areas of metabolic syndrome, provides a significant positive clinical outcome in obesity-related comorbidities and induces desirable changes in inflammatory, kidney and liver related biomarkers. PMID: 32117497 [PubMed]
Source: Videosurgery and Other Miniinvasive Techniques - Category: Surgery Tags: Wideochir Inne Tech Maloinwazyjne Source Type: research
The objective of this research article was to assess the trend of hospitalization, epidemiological characteristics and economic burden in the young adult, aged 18–45 years, presenting with atrial fibrillation.MethodsHospitalization data from the National Inpatient Sample between 2005 and 2015 were used to analyze prevalence of risk factors and financial burden in young adults with atrial fibrillation.ResultsFrom 2005 to 2015, a total of 260,080 admissions were included in the study. From 2005 to 2015, there was a decreasing trend of total admissions with atrial fibrillation among the age group of 18–45 years co...
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research
The objective of our study was to determine the prevalence, risk factors, and the impact of obstructive sleep apnea (OSA) in the adult with congenital heart disease (ACHD). One hundred forty-nine consecutive patients seen in our ACHD program were screened for OSA using the Berlin Questionnaire. Demographic and clinical details on subjects were collected through a chart review. Clinical variables were analyzed to determine risk factors for positive OSA screen, as well as associated outcomes. Seventy-seven (52%) of our cohort were females. The median age of the cohort was 33  years (range = 18–74) an...
Source: Pediatric Cardiology - Category: Cardiology Source Type: research
Obstructive sleep apnea (OSA) is a common chronic disease resulting from repetitive collapse of the airway during sleep, causing hypoxemia and sleep fragmentation. Untreated OSA at varying severity levels has been linked to hypertension, cardiac arrhythmias, stroke, diabetes, decreased work performance, decreased quality of life (QOL), and increased all-cause mortality. It is a costly global health concern as the increasing prevalence of OSA parallels the rising rates of obesity. OSA affects approximately 22% of men and 17% of women, while severe OSA is present in 2-4% of the adult population1.
Source: Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Source Type: research
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