Re: When to suspect a non-melanoma skin cancer. Is pain really a symptom of cancer?

Source: BMJ Comments - Category: General Medicine Source Type: forums

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HORSHAM, Pa., April 21, 2020 – The Janssen Pharmaceutical Companies of Johnson &Johnson announced today the U.S. Food and Drug Administration (FDA) approval of IMBRUVICA® (ibrutinib) in combination with rituximab for the treatment of patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who are new to therapy. The approval is based on positive results from the landmark Phase 3 E1912 study that was designed and conducted by the ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) and sponsored by the National Cancer Institute, part of the National Institutes of Health. Today’s mil...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
CONCLUSIONS: High-certainty evidence suggests that tofacitinib is superior to placebo for maintenance of clinical and endoscopic remission at 52 weeks in participants with moderate-to-severe UC in remission. The optimal dose of tofacitinib for maintenance therapy is unknown. High-certainty evidence suggests that there is no increased risk of AEs with tofacitinib compared to placebo. However, we are uncertain about the effect of tofacitinib on SAEs due to the low number of events. Further studies are required to look at the long-term effectiveness and safety of using tofacitinib and other oral JAK inhibitors as maintenance ...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
Erica S. Tarabadkar† and Michi M. Shinohara*† Division of Dermatology, University of Washington, Seattle, WA, United States Skin directed therapies (SDTs) serve important roles in the treatment of early stage cutaneous T-cell lymphoma (CTCL)/mycosis fungoides (MF), as well as managing symptoms and improving quality of life of all stages. There are now numerous options for topical therapies that demonstrate high response rates, particularly in early/limited MF. Phototherapy retains an important role in treating MF, with increasing data supporting efficacy and long-term safety of both UVB and PUVA as ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
As artificial intelligence tools have been invading more or less every area of healthcare, we made a list to keep track of the top smart algorithms aiming for better diagnostics, more sophisticated patient care or further sighted predictions of diseases. Does A.I. beat doctors? Only if you lived under a rock for the last couple of years, could you not have heard about artificial intelligence. Some might have even come across the spread and potential of A.I. in healthcare. Not only smart algorithms themselves but also the hype around A.I. has grown immensely, thus every time a new study about deep learning or machine...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Artificial Intelligence in Medicine AI cancer death future Health Healthcare pathology prediction Radiology technology Source Type: blogs
Authors: Nguyen K, Khachemoune A Abstract INTRODUCTION: Photodynamic therapy (PDT) involves the application of a topical photosensitizer, irradiation with light, and oxygen to produce cytotoxic reactive oxygen species that selectively destroy damaged cells while leaving normal skin intact. Topical PDT is a commonly used treatment for non-melanoma skin cancers (NMSCs) due to its excellent clearance rate and cosmetic outcomes. However, PDT is emerging as an off-label treatment modality for many dermatological conditions. METHODS: A literature review using MEDLINE was performed to identify randomized controlled tr...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Conclusion: Survivors of CML have a generally favorable outcome. However late relapses may occur (14% in our series) often requiring a change in treatment. This underscores the need to continued monitoring beyond 5 years. Co-morbidities and second malignancies may also occur in many patients, underscoring the need for a holistic follow-up of these patients.DisclosuresBose: Celgene Corporation: Honoraria, Research Funding; Incyte Corporation: Honoraria, Research Funding; Blueprint Medicines Corporation: Research Funding; Constellation Pharmaceuticals: Research Funding; Astellas Pharmaceuticals: Research Funding; Pfizer, Inc...
Source: Blood - Category: Hematology Authors: Tags: 632. Chronic Myeloid Leukemia: Therapy Source Type: research
This article is protected by copyright. All rights reserved. PMID: 30216404 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
This article is protected by copyright. All rights reserved. PMID: 30183065 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
Itch and pain have previously been shown to be associated with non-melanoma skin cancers with itch linked with more superficial basal cell carcinoma (BCC) lesions and pain associated with histologic features that involve the deeper dermal processes in squamous cell carcinoma (SCC) lesions. The mediators underlying itch and pain of non-melanoma skin cancers are poorly understood. Biopsies of skin cancer lesions (n=50) underwent immunohistochemistry for PAR2, tryptase, substance P and b-tubulin for nerve fibers.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Pathophysiology and Therapeutics Source Type: research
BACKGROUND: Despite high survival rates of non-melanoma skin cancer (NMSC), many patients report unmet supportive care needs, increased cancer-specific and general distress, and higher levels of anxious and depressive symptoms. Virtual reality (VR) has experienced tremendous growth in recent years with rapidly expanding applications. Proof of concept using VR to mitigate stressful healthcare experiences has already been demonstrated in various settings.OBJECTIVE: To assess the utility of a VR experience in the context of the Mohs surgical day as a means to ameliorate patient anxiety and pain.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Research: Patient Outcomes Research Source Type: research
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