Inhibitory activities of phenylpropanoids from Lycopus lucidus on amyloid aggregation related to Alzheimer ’s disease and type 2 diabetes

In this study, thioflavin-T assay and transmission electron microscopy were performed to evaluate the inhibitory effect of three phenylpropanoids isolated fromLycopus lucidus—schizotenuin A and lycopic acids A and B—on both Aβ and hIAPP fibrillization. All tested compounds exhibited similarly strong inhibitory activity toward amyloid aggregation. These results suggested that catechol moieties play important roles in the inhibition of amyloid plaque formation.

Source: Journal of Natural Medicines - March 25, 2020 Category: Drugs & Pharmacology Source Type: research