Performance Characteristics of a Multiplex Flow Immunoassay for Detection of IgG-Class Antibodies to Measles, Mumps, Rubella, and Varicella-Zoster Viruses in Presumptively Immune Health Care Workers Immunoassays

Immunity to measles, mumps, rubella, and varicella-zoster viruses (VZV; MMRV) is a common condition of employment for health care workers (HCWs) to ensure compliance with national standards and state laws. When documentation of complete vaccination or laboratory-confirmed infection is not available, Advisory Committee on Immunization Practices (ACIP) criteria are used to guide vaccination or anti-MMRV IgG testing. We assessed the performance of the BioPlex 2200 MMRV IgG multiplex flow immunoassay (MFI; Bio-Rad Laboratories, Hercules, CA) and matched immunofluorescence assays (IFAs; MBL Bion, Des Plaines, IL) in 220 HCWs categorized by ACIP criteria for presumptive immunity to MMRV. Among HCWs presumptively immune to measles, mumps, rubella, and VZV, the Bio-Rad MFI was positive in 77.3, 85.4, 84.3, and 91.1% of HCWs, respectively. Comparatively, the Bion IFA was positive in 92.9, 91.1, and 93.5% of HCWs presumptively immune to measles, mumps, and VZV (a rubella IFA was unavailable). Among HCWs fully vaccinated against measles, mumps, and VZV, Bio-Rad MFI/Bion IFA positivity rates were 77.4%/93%, 84.8%/90.7%, and 54.5%/90.9%, respectively. The Bio-Rad MFI was positive in 83.7% of HCWs fully vaccinated against rubella. For HCWs whose last vaccination event occurred within 15 years of enrollment, 83.3, 93.3, and 74.2% were positive by the Bio-Rad measles, mumps, and rubella IgG MFIs, respectively. We show significantly decreased Bio-Rad MFI sensitivity for detection of anti-meas...
Source: Journal of Clinical Microbiology - Category: Microbiology Authors: Tags: Immunoassays Source Type: research

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Conditions:   Pneumococcal Immunisation;   Diphtheria Immunisation;   Tetanus Immunisation;   Pertussis Immunisation;   Hepatitis B Immunisation;   Haemophilus Influenzae Type b Immunisation;   Polio Immunisation;   Measles Immunisation;   Rubella Immunisation;   Varicella Immunisation;   Mumps Immunisation Interventions:   Biological: SP0202-IIb Pneumococcal Conjugate Vaccine formulation 1;   Biological: SP0202-VI Pneumococcal Conjugate Vaccine formulation 2;   Biological: SP0202...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Human Vaccines and Immunotherapeutics - Category: Allergy & Immunology Authors: Source Type: research
Here’s betting you wouldn’t want anyone blowing smallpox scabs up your nose. But you might feel differently if you lived in 15th century China. Long ago, the Chinese recognized that people who had contracted smallpox once were immune to reinfection. They came up with the idea of preserving scabs from individuals who had suffered mild cases, drying them out, crushing them to a powder and blowing them up the nostril. For boys it was the right nostril, for girls it was the left because, well, 15th century. That is how the story of vaccines usually begins, though that version is decidedly incomplete. For one thing,...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized COVID-19 Explainer health Source Type: news
We report a case of anaphylaxis to the MMR vaccine in a new military recruit sensitized to gelatin IgE. PMID: 32395766 [PubMed - as supplied by publisher]
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
Background: New treatment options for warts include intralesional wart injection with agents such as vitamin D, measles, mumps, and rubella (MMR) vaccine antigen, Bacillus Calmette-Guerin (BCG) antigen, and candida antigen but there have been limited studies to compare their efficacies. Background: New treatment options for warts include intralesional wart injection with agents such as vitamin D, measles, mumps, and rubella (MMR) vaccine antigen, Bacillus Calmette-Guerin (BCG) antigen, and candida antigen but there have been limited studies to compare their efficacies. Objective: The purpose of this systematic review is to...
Source: Dermatology Online Journal - Category: Dermatology Source Type: research
Condition:   Mumps Interventions:   Biological: Mumps vaccine;   Biological: measles, mumps and rubella combined vaccine, live Sponsor:   Sinovac (Dalian) Vaccine Technology Co., Ltd. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
GPs worried thousands may delay routine appointments due to fear of catching coronavirusCoronavirus – latest updatesSee all our coronavirus coverageSenior doctors fear that thousands of routine vaccination appointments may be missed or delayed because of the coronavirus lockdown, raising the risk of sudden and potentially fatal outbreaks of other diseases when restrictions on movement are finally eased.GPs and accident and emergency departments have witnessedunprecedented falls in the numbers of people seeking medical care in recent weeks, prompting concerns that vital routine immunisations for infections such as mea...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Vaccines and immunisation Health Coronavirus outbreak Infectious diseases Society Science Medical research Source Type: news
FRIDAY, April 24, 2020 -- Measles, mumps, and rubella (MMR) vaccines and MMR vaccines with varicella are effective and safe, according to an updated review published online April 20 in the Cochrane Database of Systematic Reviews. Carlo Di...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
FRIDAY, April 24, 2020 -- Measles, mumps, and rubella (MMR) vaccines and MMR vaccines with varicella are effective and safe, according to an updated review published online April 20 in the Cochrane Database of Systematic Reviews. Carlo Di...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
The Measles virus (MeV) and Mumps virus (MuV) are highly contagious paramyxoviruses that can be transmitted by respiratory droplets from or on direct contact with an infected person. The resulting diseases can lead to serious complications or death among children. The existing vaccines for MeV and MuV are live attenuated virus vaccines which are administered in two subcutaneous doses at 1 year of age and as early as one month later. Two doses of a combination measles, mumps and rubella vaccine are 97% effective against measles and 88% against mumps. A single dose of a combination measles, mumps, and rubella vaccine is 93% ...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research
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