Intraventricular dopamine infusion alleviates motor symptoms in a primate model of Parkinson's disease.

CONCLUSION: Continuous circadian i.c.v. of A-dopamine appears to be feasible and shows efficacy without dyskinesia with a safe therapeutic index.
PMID: 32205254 [PubMed - as supplied by publisher]

Source: Neurobiology of Disease - March 19, 2020 Category: Neurology Authors: Moreau C, Rolland AS, Pioli E, Li Q, Odou P, Barthelemy C, Lannoy D, Demailly A, Carta N, Deramecourt V, Auger F, Kuchcinski G, Laloux C, Defebvre L, Bordet R, Duce J, Devedjian JC, Bezard E, Fisichella M, David D Tags: Neurobiol Dis Source Type: research