Stress-induced impairment in fear discrimination is causally related to increased kynurenic acid formation in the prefrontal cortex

ConclusionsThese findings demonstrate a causal connection between stress-induced KYNA increases and cognitive deficits. Pharmacological manipulation of KYNA synthesis therefore offers a novel approach to modulate cognitive processes in stress-related disorders.

Source: Psychopharmacology - March 24, 2020 Category: Psychiatry Source Type: research