The long non-coding RNA PVT1/miR-145-5p/ITGB8 axis regulates cell proliferation, apoptosis, migration and invasion in non-small cell lung cancer cells.

In conclusion the knockdown of PVT1 inhibited proliferation, migration and invasion but induced apoptosis of NSCLC cells by regulating miR-145-5p/ITGB8 axis and inhibiting MEK/ERK signaling pathway, providing a novel avenue for the treatment of NSCLC.
PMID: 32202906 [PubMed - as supplied by publisher]

Source: Neoplasma - March 23, 2020 Category: Cancer & Oncology Authors: Wei CM, Zhao XF, Qiu HB, Ming Z, Liu K, Yan J Tags: Neoplasma Source Type: research