N-terminal [Glu]3 moiety of γ-glutamyl peptides contributes largely to the activation of human calcium-sensing receptor, a kokumi receptor.

In this study, the relationship between γ-glutamyl peptide structure and hCaSR activity was systematically analyzed using γ-[Glu](n=0-4)-α-[Glu](n=0-3)-Tyr. Our results suggest that N-terminal [Glu]3 moiety is very important for hCaSR activities of γ-glutamyl peptides.
PMID: 32202205 [PubMed - as supplied by publisher]

Source: Bioscience, Biotechnology, and Biochemistry - March 20, 2020 Category: Biochemistry Authors: Yamamoto M, Terada Y, Motoyama T, Shibata M, Saito T, Ito K Tags: Biosci Biotechnol Biochem Source Type: research