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ERGIC-53's role in virus propagation suggested by bleeding symptom

Rodent-borne pathogens like hantaviruses and arenaviruses are simple, but resourceful, and very successful at propagating. Due to a tiny genome generating a mere four proteins compared to humans' thousands, they rely on human biological machinery to do their replication dirty work, facilitating infection, plus a high mortality rate. Vermont researchers have discovered a mechanism that when targeted, may stop these deadly viruses in their tracks.A new study published in Cell Host &Microbe by the University of Vermont's Jason Botten, Ph.D.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

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[Guardian] A recent study has shown how substandard drug used to stop post partum haemorrhage (PPH) fuels maternal deaths in Nigeria. Earlier studies had identified PPH as the leading cause of maternal mortality across the country.
Source: AllAfrica News: Pregnancy and Childbirth - Category: OBGYN Source Type: news
This article aims to discuss the problem of AF in dialysis patients, summarise the current evidence around the use of oral anticoagulants for AF in ESRD and provide some practical suggestions on management of AF in the haemodialysis population.
Source: British Journal of Haematology - Category: Hematology Authors: Tags: Review Source Type: research
Summary A few decades ago, the chances of survival for patients with a haematological malignancy needing Intensive Care Unit (ICU) support were minimal. As a consequence, ICU admission policy was cautious. We hypothesized that the long‐term outcome of patients with a haematological malignancy admitted to the ICU has improved in recent years. Furthermore, our objective was to evaluate the predictive value of the Acute Physiology and Chronic Health Evaluation (APACHE) II score. A total of 1095 patients from 5 Dutch university hospitals were included from 2003 until 2015. We studied the prevalence of patients' characteristi...
Source: British Journal of Haematology - Category: Hematology Authors: Tags: Research Paper Source Type: research
BACKGROUND Resuscitative endovascular balloon occlusion of the aorta (REBOA) is increasingly used as a noninvasive clamp of the aorta after diverse posttraumatic injuries. Balloon inflation in zone 3 (from the lower renal artery to the aortic bifurcation) can be performed to stop ongoing bleeding after severe pelvic trauma with life-threatening hemorrhage. The aim of our study was to describe our 20-year experience with REBOA in terms of efficacy and safety in patients with a suspicion of severe pelvic trauma and extreme hemorrhagic shock. METHODS We performed a retrospective study from 1996 to 2017 in a French Level ...
Source: The Journal of Trauma: Injury, Infection, and Critical Care - Category: Orthopaedics Tags: Original Articles Source Type: research
CONCLUSION The majority of traumatic hemorrhagic prediction studies are of poor quality, as assessed by the Prognosis Research Strategy recommendations and Critical Appraisal and Data Extraction for Systematic Reviews of Modeling Studies checklist. There exists a need for a well-designed clinical prediction model for early identification of patients requiring intervention. The variables of clinical importance identified in this review are consistent with recent expert guideline recommendations and may serve as candidates for future derivation studies.
Source: The Journal of Trauma: Injury, Infection, and Critical Care - Category: Orthopaedics Tags: Systematic Review Source Type: research
The optimal time to endoscopy in patients with a high-risk of upper GI bleeding is unknown. In this issue of Clinical Gastroenterology and Hepatology, Cho and colleagues1 compared outcomes between high-risk patients (defined as Glasgow-Blatchford score> 7) who underwent “urgent endoscopy” within 6 hours (n = 571) to those who underwent “elective endoscopy” between 6-48 hours (n = 390). Patients undergoing urgent endoscopy had a higher proportion of active hemorrhage on endoscopy and need for endoscopic intervention.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Issue highlights Source Type: research
Authors: Meynardi F, Lauritano D, Pasqualini ME, Rossi F, Grivet-Brancot L, Comola G, Dal Carlo L, Moglioni E, Zampetti P Abstract The presence of periodontal disease can be ascertained by clinical examination (redness, edema and probe depth, bleeding-on-probing). Occlusal adjustment can lead to a marked, stable improvement in periodontal health in terms of bacterial profile and clinical appearance, presumably by obviating tissue distress caused by occlusal dysfunction, thereby providing unfavorable conditions for bacterial growth. Therefore, occlusal trauma can be an essential indicator of the periodontal disease ...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
We greatly appreciate Ms Barbey's interest in our paper and acknowledge the inherent limitations of retrospective registry-based studies. As for the design of the registry, only data for patients undergoing abdominal aortic aneurysm (AAA) repair are available. Consequently, information on patients not surviving their rupture or on surviving patients who were not considered eligible for repair is missing. Although we acknowledge that this may influence the AAA diameter-at-rupture distribution (namely, larger diameters could carry a greater risk for fatal bleeding), we do not have indications for significant sex-specific inf...
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Letter to the Editor Source Type: research
Authors: Luo X, Shi W, Zhang X, Yang X, Wang W, Zeng C, Wang H Abstract An elderly male patient with coronary heart disease underwent coronary angiography, which revealed bilateral severe coronary artery stenosis. Four stents were implanted, and at 5 h post-surgery, typical hemorrhagic shock appeared. Echocardiography verified heavy bleeding in the right thoracic cavity. Emergency angiography excluded injury or perforation of the coronary artery, aorta, right subclavian artery and brachiocephalic artery. Considering the patient's history of chronic obstructive pulmonary disease and severe cough during the operation...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
VISION loss includes difficult reading, driving at night, or seeing washed out colours. This woman was cured of her sight problems - including bleeding from the eye - with this quick treatment.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
More News: Arenaviruses | Bleeding | Hantavirus | Health | Infectious Diseases | Study