ERGIC-53's role in virus propagation suggested by bleeding symptom

Rodent-borne pathogens like hantaviruses and arenaviruses are simple, but resourceful, and very successful at propagating. Due to a tiny genome generating a mere four proteins compared to humans' thousands, they rely on human biological machinery to do their replication dirty work, facilitating infection, plus a high mortality rate. Vermont researchers have discovered a mechanism that when targeted, may stop these deadly viruses in their tracks.A new study published in Cell Host &Microbe by the University of Vermont's Jason Botten, Ph.D.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

Related Links:

CONCLUSIONS: Based on the results with low rate of major adverse effects from multiple centers, we concluded that HIFU is safe in treating patients with benign uterine diseases. With development of this technique and more experience on the part of the physicians, the rates of the major adverse effects will be further lowered. PMID: 29792359 [PubMed - as supplied by publisher]
Source: International Journal of Hyperthermia - Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research
Authors: Lipiecki J, Brunel P, Morice MC, Roguelov C, Walsh SJ, Richardt G, Eerdmans P, Zambahari R, Berland J, Copt S, Stoll HP, Urban P Abstract AIMS: The LEADERS FREE trial has demonstrated that a polymer-free Biolimus A9-coated stent (BA9-DCS) is superior to a bare metal stent (BMS) for high bleeding risk (HBR) patients when treated with one month of dual antiplatelet therapy (DAPT). This analysis aimed to determine the impact of PCI procedure complexity on the two-year results. METHODS AND RESULTS: Six hundred and sixty-seven (667) patients enrolled in the LEADERS FREE (BA9-DCS 346, BMS 321) underwent a co...
Source: EuroIntervention - Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research
CONCLUSIONS: This is the first study providing clinical evidence on the use of PF-BES in all-comer patients irrespective of HBR status. Our findings suggest that PF-BES has a favorable safety and efficacy profile in a real world clinical setting. Further investigation in randomised clinical trials against new-generation DES is warranted. PMID: 29784631 [PubMed - as supplied by publisher]
Source: EuroIntervention - Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research
Authors: Favaloro EJ, Bonar R Abstract Testing of platelet function comprises a crucial element of hemostasis assessment, particularly for investigations into bleeding and/or bruising. The Platelet Function Analyzer (PFA)-100 is the most utilized primary hemostasis-screening test system available, as recently remodeled/upgraded to the PFA-200. Internal quality control (IQC) and external quality assessment (EQA) (including proficiency testing) represent critical elements of ensuring test practice quality. Although true for all tests, IQC and EQA are logistically challenging for platelet function testing, inclusive o...
Source: Platelets - Category: Hematology Tags: Platelets Source Type: research
are: Infra inguinal bypass using prosthetic material Bypass below the knee Use of sub optimal conduit Poor arterial runoff Extensive lesion When these risk factors are noted, anti thrombotic therapy can be intensified by adding either rivaroxaban or warfarin to aspirin. Another option is to give dual antiplatelet therapy. While intensifying therapy, risk of limb loss should be weighed against the potential bleeding risk in each individual. Triple therapy with two antiplatelet agents and one anticoagulant is better avoided in view of high bleeding risk. The post Factors enhancing risk of limb loss after revascularization...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: Peripheral Interventions Source Type: blogs
Conclusions The use of cryoprobes with heat-based track ablation did not decrease the incidence of bleeding complications after renal cryoablation compared with procedures performed without track ablation.
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
Publication date: June 2018 Source:Journal of Vascular and Interventional Radiology, Volume 29, Issue 6 Author(s): Stanley Baum
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
Publication date: 10 August 2018 Source:Neuroscience Letters, Volume 681 Author(s): Lisbeth Kristensson, Anders Lundin, David Gustafsson, Jan Fryklund, Tomas Fex, Louise Delsing, Erik Ryberg Plasminogen binding inhibitors (PBIs) reduce the risk of bleeding in hemorrhagic conditions. However, generic PBIs are also associated with an increased risk of seizures, an adverse effect linked to unwanted activities towards inhibitory neuronal receptors. Development of novel PBIs serve to remove compounds with such properties, but progress is limited by a lack of higher throughput methods with human translatability. Herein we apply...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Venous thromboembolism (VTE) prophylaxis guidelines for non-surgical patients recommend VTE- and bleeding risk assessment to guide prophylactic strategies. These recommendations differ between guidelines and implementation is suboptimal. Assessing a guideline's implementability characteristics helps predicting the ease of implementation and reveals barriers.
Source: Thrombosis Research - Category: Hematology Authors: Tags: Full Length Article Source Type: research
Publication date: Available online 26 May 2018 Source:Revista Española de Cardiología (English Edition) Author(s): John García, Gustavo Jiménez-Brítez, Eduardo Flores-Umanzor, Guiomar Mendieta, Xavier Freixa, Manel Sabaté
Source: Revista Espanola de Cardiologia - Category: Cardiology Source Type: research
More News: Arenaviruses | Bleeding | Hantavirus | Health | Infectious Diseases | Study