ERGIC-53's role in virus propagation suggested by bleeding symptom

Rodent-borne pathogens like hantaviruses and arenaviruses are simple, but resourceful, and very successful at propagating. Due to a tiny genome generating a mere four proteins compared to humans' thousands, they rely on human biological machinery to do their replication dirty work, facilitating infection, plus a high mortality rate. Vermont researchers have discovered a mechanism that when targeted, may stop these deadly viruses in their tracks.A new study published in Cell Host &Microbe by the University of Vermont's Jason Botten, Ph.D.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

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Yaxin Wang, Yajun Li, Xiangwei Meng, Xiumei Duan, Meilan Wang, Wenqing Chen, Tongyu Tang, Yuqin Li
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In this study, we examined the effects of branched silicon tube (BST) and temporary closed circle (TCC) in a Beagle dog model of multiple transection of small intestine and discontinuities suspected intestinal necrosis with hemorrhagic shock. MATERIALS AND METHODS: Ten male Beagle dogs were randomly divided into two groups. Hemorrhagic shock was induced by bleeding. Intestine was severed. Suspected intestinal necrotic model by ligating the mesenteric vessels was established, with a small tertiary mesenteric vessel reserved. Fracted intestines were ligated (IL group, n = 5) or reconnected with BST (IR grou...
Source: Journal of Investigative Surgery - Category: Surgery Tags: J Invest Surg Source Type: research
Authors: Fujimura M, Tominaga T Abstract Moyamoya disease (MMD) is a progressive cerebrovascular disease with unknown etiology, characterized by bilateral stenoocclusive changes at the terminal portion of the internal carotid artery and an abnormal vascular network formation at the base of the brain. MMD has an intrinsic nature to convert the vascular supply for the brain from internal carotid (IC) system to the external carotid (EC) system, as indicated by Suzuki's angiographic staging. Insufficiency of this 'IC-EC conversion system' could result not only in cerebral ischemia, but also in intracranial hemorrhage f...
Source: Journal of Korean Neurosurgical Society - Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research
CONCLUSION: The Solomon Islands presents a unique profile of challenges to surgical practice, including the impact of dengue infection on fitness for surgery, a mobile patient population dispersed across the islands, difficult access to pathology services, and increased length of stay. Despite this, most patients had surgical outcomes equivalent to those in a developed setting. PMID: 30433793 [PubMed - in process]
Source: Rural and Remote Health - Category: Rural Health Tags: Rural Remote Health Source Type: research
Authors: Hellgren M, Mistafa O Abstract A systematic review of studies published between 1 January 1985 and 31 August 2017 was performed to analyse the efficacy of the low-molecular-weight heparin, dalteparin, in venous thromboembolism (VTE) treatment and prophylaxis during pregnancy, and to evaluate dosing practices, anticoagulant monitoring and adverse events. A therapeutic dosing throughout pregnancy or followed by reduced doses effectively prevented VTE recurrence. Anti-factor Xa activity was the most commonly used method of dose monitoring. The risk of bleeding with dalteparin was generally minor. Major bleedi...
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
ConclusionA tumor located in the pancreatic head or mesenteric side of the duodenum cannot always be diagnosed based on imaging, and is ideally diagnosed histologically to guide the extent of resection. While EUS-FNA can establish the diagnosis, the complications of this procedure must be considered.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
We present a case of 26-day- female who presented with abdominal distension, bilious vomiting and bleeding per rectum. The initial diagnosis was intestinal obstruction due to volvulus or malrotation On exploratory laparotomy, it turned out to be a case of ileo-ileal intussusception without any leading point. This site of intussusception (ileo-ileal) and without any leading point (idiopathic or primary intussusception) among neonate is of exceedingly rare occurrence and very few such cases have been reported. In this article, the published work about clinical features and management on intussusceptions in neonatal period an...
Source: Journal of Pediatric Surgery Case Reports - Category: Surgery Source Type: research
Publication date: Available online 15 November 2018Source: Current Medicine Research and PracticeAuthor(s): K.M. Mahendra, Gaurav Gangwani, Ajit Yadav, Arun GuptaAbstractPercutaneous selective Arterial Embolization is increasingly being used to control intractable hemorrhage in emergency setting. Here we describe management of a patient of post Caeserean section bleed from left Inferior epigastric artery who presented with vaginal bleeding, abdominal wall haematoma, dissecting into peritoneal cavity and resulting in hemoperitoneum.CT Angiography demonstrated extravasation of contrast from left Inferior epigastric artery. S...
Source: Current Medicine Research and Practice - Category: General Medicine Source Type: research
ConclusionSepsis at referral, liver cirrhosis, and operative bleeding were significantly associated with both early and late morbidities after definitive management of laparoscopic cholecystectomy related major bile duct injuries, so it is crucial to avoid these catastrophes when doing those major procedures.
Source: Annals of Medicine and Surgery - Category: General Medicine Source Type: research
Conclusion: The present study suggests that young age (under 60  years old) and large polyp size are risk factors for causing delayed hemorrhage after colonic EMR in patients without antithrombotic therapy.Digestion
Source: Digestion - Category: Gastroenterology Source Type: research
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