External Validation of a Pharmacokinetic Model of Propofol for Target-Controlled Infusion in Children under Two Years Old.

CONCLUSION: The pooled bias and inaccuracy of the pharmacokinetic predictions are clinically acceptable. Therefore, our external validation of the Kim model indicated that the model can be applicable to target-controlled infusion of propofol in children younger than 2 years, with the recommended use of actual bispectral index monitoring in clinical settings that remifentanil is present. Trial Registration Clinical Research Information Service Identifier.
TRIAL REGISTRATION: Clinical Research Information Service Identifier: KCT0001752.
PMID: 32193901 [PubMed - in process]

Source: J Korean Med Sci - March 21, 2020 Category: General Medicine Authors: Ji SH, Lee JH, Cho JY, Kim HS, Jang YE, Kim EH, Kim JT, Kim HS Tags: J Korean Med Sci Source Type: research