U-shaped associations between urinary iodine concentration and the prevalence of metabolic disorders: a cross-sectional study.

This study aimed to investigate the relationship between iodine status and metabolic disorders, such as metabolic syndrome, hypertension, impaired glucose metabolism, central obesity and dyslipidemia. METHODS: 51,795 subjects aged ≥18 years from the TIDE (Thyroid Disorders, Iodine Status and Diabetes, a national epidemiological cross-sectional study) program were included. The prevalence of metabolic disorders and its related diseases were calculated based on the level of urinary iodine concentrations (UICs) using the chi-square method. To further explore whether prevalence was associated with UIC, quadratic and UIC-stratified logistic regression models were used. RESULTS: The prevalence of metabolic disorders as a function of UIC was found to be U-shaped with a lower prevalence of 76.0% at a UIC of 300-499 µg/L. Participants with UIC of 300-499 µg/L were associated with metabolic disorders [OR=0.857, 95%CI (0.796-0.922)] and hypertension [OR=0.873, 95%CI (0.814-0.936)]. A UIC of 300-799 µg/L was found to be associated with against the occurrence of metabolic syndrome (MetS) and impaired fasting glucose (IFG). UIC of 500-799 µg/L was associated with the occurrence of prediabetes [OR=0.883, 95%CI (0.797-0.978)]. UIC ≥300 µg/L was associated with the occurrence of hypertriglyceridemia, hypercholesterolemia, and high levels of low density lipoprotein cholesterol (LDL-C). Furthermore, a UIC of
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research

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Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research
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Source: Acta Haematologica - Category: Hematology Authors: Tags: Acta Haematol Source Type: research
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Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
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Source: Journal of Hypertension - Category: Cardiology Tags: ORIGINAL PAPERS: Epidemiology Source Type: research
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Source: Drug Discoveries and Therapeutics - Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research
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