Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes due to m.3243A   >  G mutation in a 76-year-old woman

Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) with m.3243A  > G mutation is a common type of mitochondrial disease [1,2]. Most patients with MELAS develop stroke-like episodes before the age of 40, a criterion of MELAS [3]. However, increasing reports have demonstrated that elderly subjects (≥ 60 years old) may develop this mitochondrial encephalopathy [4,5]. Here, we report a 76-year-old woman who was previously healthy without any organ dysfunction related to mitochondrial abnormalities (except for a mild hearing disability) and developed encephalopathy accompanied by stroke-like episodes and non-convulsive status epilepticus (NCSE).

Source: Journal of the Neurological Sciences - March 18, 2020 Category: Neurology Authors: Kana Ueki, Yoshinobu Wakisaka, Kuniyuki Nakamura, Yuji Shono, Shinichi Wada, Yoji Yoshikawa, Yuta Matsukuma, Takeshi Uchiumi, Dongchong Kang, Takanari Kitazono, Tetsuro Ago Tags: Letter to the Editor Source Type: research