P2Y6 receptor inhibition aggravates ischemic brain injury by reducing microglial phagocytosis.

CONCLUSION: Our results indicate that P2Y6 receptor-mediated microglial phagocytosis plays a beneficial role during the acute stage of ischemic stroke, which can be a therapeutic target for ischemic stroke.
PMID: 32154670 [PubMed - as supplied by publisher]

Source: CNS Neuroscience and Therapeutics - March 9, 2020 Category: Neuroscience Authors: Wen RX, Shen H, Huang SX, Wang LP, Li ZW, Peng P, Mamtilahun M, Tang YH, Shen FX, Tian HL, Yang GY, Zhang ZJ Tags: CNS Neurosci Ther Source Type: research