Long-term changes in metabolic brain network drive memory impairments in rats following neonatal hypoxia-ischemia.

CONCLUSIONS: Our findings demonstrated that long-term changes in MBN drive memory impairments in adult rats subjected to neonatal hypoxic ischemia, using in vivo imaging microPET-FDG. The MBN analyses identified glucose metabolism abnormalities in HI non-h animals, which were not detected by conventional 18F-FDG standardized uptake value (SUVr) measurements. These animals exhibited a metabolic brain signature that may explain the cognitive deficit even with no identifiable brain damage.
PMID: 32147586 [PubMed - as supplied by publisher]

Source: Neurobiology of Learning and Memory - March 4, 2020 Category: Neurology Authors: Nunes Azevedo P, Zanirati G, Teribele Venturin G, Garcia Schu G, Elena Durán-Carabali L, Kawa Odorcyk F, Vinicius Soares A, de Oliveira Laguna G, Alexandre Netto C, Rigon Zimmer E, Costa da Costa J, Greggio S Tags: Neurobiol Learn Mem Source Type: research