Severe hypokalemia and rebound hyperkalemia during barbiturate coma in patients with severe traumatic brain injury.

CONCLUSIONS: Severe hypokalemia refractory to medical treatment and rebound hyperkalemia is a serious adverse effect of thiopentone coma therapy in patients with severe TBI. Excessive and aggressive potassium replacement during the barbiturate-induced hypokalemia period must be avoided. Weaning barbiturate treatment over time may be advantageous in the management of severe serum potassium disturbances. PMID: 32146086 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32146086?dopt=Abstract

Source: Neurocirugia - March 3, 2020 Category: Neurosurgery Authors: Aytuluk HG, Topcu H Tags: Neurocirugia (Astur) Source Type: research