Testing for Hepatitis C - The Importance for People With Cancer

I know it's kind of off the topic, but you may have been hearing the news about testing for hepatitis C. The news isn't really new - what's new is that the public is finally being informed. For years physicians have known that hepatitis C is the leading cause of liver cancer - and the leading cause of liver transplants....Read Full Post
Source: About.com Lung Cancer - Category: Cancer & Oncology Source Type: news

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Although immune checkpoint inhibitors (ICIs) have improved survival in many patients with non-small cell lung cancer (NSCLC), [1] our understanding of the safety and efficacy of these therapies in certain populations is limited. Patients with past2 or chronic [1] hepatitis B (HBV) or hepatitis C virus (HCV) infections, for example, have been excluded from most of the pivotal phase 3 immunotherapy clinical trials in lung cancer [1,2], so there is a paucity of data both on the risks of viral reactivation or flare, and on the rates of hepatotoxicity in these patients after treatment with ICIs.
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
Publication date: August 2019Source: Current Opinion in Virology, Volume 37Author(s): Jonathan Stern, George Miller, Xin Li, Deepak SaxenaAlthough bacterial dysbiosis has been previously associated with carcinogenesis and HIV infection, the impact of the virome and these disease states has been less well studied. In this review, we will summarize what is known about the interplay between both the bacterial and the viral components of the microbiome on cancer and HIV pathogenesis. Bacterial dysbiosis has been associated with carcinogenesis such as colorectal cancer (CRC), hepatocellular carcinoma (HCC), lung cancer, breast ...
Source: Current Opinion in Virology - Category: Virology Source Type: research
Immunotherapy, Ahead of Print.
Source: Immunotherapy - Category: Allergy & Immunology Authors: Source Type: research
Discussion MDSCs violently emerge in pathological conditions in an attempt to limit potentially harmful immune and inflammatory responses. Mechanisms supporting their expansion and survival are deeply investigated in cancer, in the perspective to reactivate specific antitumor responses and prevent their contribution to disease evolution. These findings will likely contribute to improve the targeting of MDSCs in anticancer immunotherapies, either alone or in combination with immune checkpoint inhibitors. New evidence indicates that the expansion of myeloid cell differentiation in pathology is subject to fine-tuning, as its...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Christine I. Alston1,2 and Richard D. Dix1,2* 1Department of Biology, Viral Immunology Center, Georgia State University, Atlanta, GA, United States 2Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA, United States Suppressor of cytokine signaling (SOCS) proteins provide selective negative feedback to prevent pathogeneses caused by overstimulation of the immune system. Of the eight known SOCS proteins, SOCS1 and SOCS3 are the best studied, and systemic deletion of either gene causes early lethality in mice. Many viruses, including herpesviruses such as herpes simplex virus and cytomega...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
We examined the level of fragile histidine triad (FHIT) and p16 gene methylation in patients with hepatocellular carcinoma and explored the relationship to liver cancer. MATERIAL AND METHODS There were 56 patients with primary liver cancer who were admitted to the hospital from July 2015 to October 2017 included in the liver cancer group, and 24 non-hepatoma patients (hepatitis A/hepatitis B/hepatitis C, liver cirrhosis, liver fibrosis, and fatty liver, alcoholic liver identified as a control group. Fasting venous blood samples were collected from the 2 groups. Methylation-specific PCR (MSP) was used to detect the methylat...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
By HANS DUVEFELT MD  I pay $500 per year for UpToDate, the online reference that helps me stay current on diagnostic criteria and best treatment options for most diseases I might run into in my practice. They also have a rich library of patient information, which I often print out during office visits. I don’t get any “credit” for doing that, but I do if I print the, often paltry, patient handouts built into my EMR. That was how the rules governing meaningful use of subsidized computer technology for medical offices were written. If I describe in great detail in my office note how I motivated a patie...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Patients Physicians EMR Hans Duvefelt primary care Source Type: blogs
Conclusion: The current study elucidated the prevalence of HBV and HCV among large population of solid cancers and lymphoma and we showed that hepatitis B and C positivity rates are significantly increased in certain solid tumors. Our findings should also be clarified with large prospective studies.
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
ConclusionsNRP1 is a novel tumor marker in HCC.
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
CONCLUSIONS: NRP1 is a novel tumor marker in HCC. PMID: 29966621 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Chemistry - Category: Chemistry Authors: Tags: Clin Chim Acta Source Type: research
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