Activation of either the ETA or the ETB receptors is involved in the development of electrographic seizures followed intrahippocampal infusion of the endothelin-1 in immature rats.

Activation of either the ETA or the ETB receptors is involved in the development of electrographic seizures followed intrahippocampal infusion of the endothelin-1 in immature rats. Exp Neurol. 2014 Dec 24; Authors: Tsenov G, Vondraková K, Otáhal J, Burchfiel J, Kubová H Abstract The period around birth is a risky time for stroke in infants, which is associated with two major acute and subacute processes: anatomical damage and seizures. It is unclear to what extent each of these processes independently contributes to poor outcome. Furthermore, it is unclear whether there is an interaction between the two processes - does seizure activity cause additional brain damage beyond that produced by ischemia and/or does brain damage foster seizures? The model of focal cerebral ischemia induced by the intrahippocampal infusion of the endothelin-1 (ET-1) in 12-day-old rat was used to examine the role of the endothelin receptors in the development of focal ischemia, symptomatic acute seizures and neurodegeneration. ET-1 (40pmol/1μl) was infused either alone or co-administered with selective antagonists of ETA (BQ123; 70nmol/1μl) or ETB receptors (BQ788; 70nmol/1μl). Effects of activation of ETB receptors were studied using selective agonist 4-Ala-ET-1 (40pmol/1μl). Regional cerebral blood flow (rCBF) and tissue oxygenation (pO2) were measured in anesthetized animals with Doppler-flowmeter and a pO2-sensor, respectively. Seizure development...
Source: Experimental Neurology - Category: Neurology Authors: Tags: Exp Neurol Source Type: research